One that's been on my "to read" list for many years, but I'm finally getting around to it now. Ayn Rand's The Fountainhead.
While Frank Lloyd Wright is clearly the model for Roark (though Wright was always a popular architect) less discussed is Henry Cameron is based on Wright's mentor Louis Sullivan. Like Cameron, Sullivan looked for an American style of architecture not based on historical precedents. His form of architecture stalled when the Chicago world's fair of 1893 triggered a massive Greek Revival building tread across the US. This, and his alcoholism, saw his career fade away. Wright helped him financially during this time.
I always thought it would make a great mini-series (the movie is most unfortunate.) It's got everything including a fetishistic form of sex in which ***Spoiler alert*** Dominique will only sleep with Roark when she stymies his career (nobody is good enough for his talent.) It doesn't get kinkier than that. However to read Rand means skipping, or ignoring, much of her philosophical writings in the book.