Here is a little bit of information. I may not be the best person to recommend hotels since I never used one over there !
It looks like you went to Les Baux de Provence but I really love the Luberon so it may worth to also go to Bonnieux and Lacoste. Beautiful villages and the drive is scenic.
You can also go to Lourmarin for the day, visit Michel Tardieu (from tardieu Laurent). The winery is like 5mn away from the village which is lovely.
Of course being from Isle sur la Sorgue I'm biased but it has changed a lot from the time I was living there. Much more touristy now and lost its soul somehow. Still market days are fantastic and I miss that. Just buy local fresh veggies and fruits, a bottle of wine and you're set !
Fontaines de Vaucluse is fun. Half a day is way enough. Barely 15mn from l'Isle.
Carpentras and Cavaillon are ok but I would personally not waste time there. But again, this is personnal.
Don't forget that everything will be closed on Mondays.
As it has already been said, Le Vivier is a nice restaurant and Christian Etienne has a great reputation (never been there myself).
Of course l'Ousteau de Baumanieres may be the best restaurant of the entire region.
Chateauneuf du Pape is like 30mn from l'Isle so easy car ride. Many places if course to visit there. Some of my faves to visit include Charvin, Nerthe, Vieux telegraphe and Bonneau.
For lunch, if you have not tried it last time, go to La Mere Germaine. All the locals are going there and the food is typically Provencale and the wine list has one or two CdP :-)
http://www.lameregermaine.com/Between Avignon and Aix, many worthy wineries to visit. Some I really like are:
-Trevallon
http://www.domainedetrevallon.com/-Domaine du Deffends (25miles from Aix)
http://www.deffends.com/SiteV4...h/index_english.html-Domaine Hauvette
-Chateau Simone
-Domaine Henri Milan
I lived 2 years in Aix-en-Provence and totally loved it as a student. The city is full of small streets, cafes, international students (but in the summer it should be more tourists than students!). I really think it worth spending at least half a day just walking around the city. Grab a coffe on the Cours Mirabeau and just people watch. The restaurant of Pierre Reboul in Aix is really good if you like modern cuisine.
If you have time, it is totally worthy to go to Bandol and Cassis. Have lunch on the port. Lovely cities but it can be crowded in the summer (it will be crowded). When in Bandol, hit the Maison des Vins de Bandol. Best way to taste a bunch of Bandols if you don't have time to visit the wineries and you can buy the wines at the winery pricing. Drive around, views are simply awesome.
I'll try to think of other places to recommend.