For messing around in my basement, my favorite guitar is a knockoff of a Gibson ES335 that I bought for around $200. It is just an extremely versatile,guitar.
For turning up my amp to "11", it's the Les Paul.
I have 2 strats and I find myself rarely playing them. I just prefer humbuckers over single coil pickups. Sometimes the song demands playing a strat (Clapton, Hendrix, SRV)