Some interesting suggestions, the kind of which I was looking for. We definitely plan on the Uffizi. We are staying inside the walls of Siena and look forward to wandering around there. We are going to do a small group tour for a day around the Siena area. Also planning on the Borghese and the Spanish Steps. There is a suggested walking route by Steves that takes us around that area. Also thinking of going to Murano and yes I am a boat person. I have sailed small boats most of my life.
Thanks and appreciate more suggestions.