TT, have you been to a Rome and/or Florence before? Wondering if you have seen the major attractions already such as Colosseum, Vatican, Uffizi, etc. Depending on where you stay in those two cities, you can situate yourself close enough to be easy walking/public transportation distance to a bunch of things. While I’m far from one of the more seasoned travelers on this forum, I’ve. Been to those cities in 2013 and 2018. Never rented a car in Italy. Look into Hotel IQ Roma. Fairly close to Termini station and if you are energetic, not a bad walk to the Colosseum.