Another very important variable is body mass. A healthy 220 lb man NEEDS to drink nearly twice as much wine as a 110 lb woman to get similar benefits. Apart from the alcohol, red wines add polyphenols which have many additional health benefits. So, I am 6'2" and 230, and drink two 6-8 oz glasses per night. I do away with a bottle every other day. The measure of too much is by blood alcohol level. Generally it's a good idea to let your doctor know how much you drink (he drinks more than me) and stay on top of you liver function.