Perhaps a state government, or the federal government, should require people to have immunizations (in the absence of a real medical contraindication or a sincerely held religious belief).
See, Jacobson v. Massachusetts, 197 US 11 (1905)
I don't think government inforcement is needed, nor desirable. Just for private businesses to require vaccination to use them. Any private businesses that want to protect their employees will require customers to be vaccinated.